ParkinsonCanadaV1, Main, Exploration, bibRecord, 001207

Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals

Identifieur interne : 001207 ( Main/Exploration ); précédent : 001206; suivant : 001208

Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals

Auteurs : Andrew S. P. Lim [États-Unis, Canada] ; Lei Yu [États-Unis] ; Madalena D. Costa [États-Unis] ; Sue E. Leurgans [États-Unis] ; Aron S. Buchman [États-Unis] ; David A. Bennett [États-Unis] ; Clifford B. Saper [États-Unis]

Source :

Sleep [ 0161-8105 ] ; 2012.

RBID : PMC:3321422

Abstract

Study Objectives:

Aging is accompanied by changes in cognitive function, and changes in rest-activity patterns. Previous work has demonstrated associations between global rest-activity measures and cognitive performance on a number of tasks. Recently, we demonstrated that aging is associated with changes in the minute-to-minute fragmentation of rest-activity patterns in addition to changes in amounts of rest and activity. Given the body of experimental evidence linking sleep fragmentation with decrements in cognitive function in animals and humans, we hypothesized that increased fragmentation of rest-activity patterns would be associated with decreased cognitive function in older individuals.

Design:

Cross-sectional.

Participants:

700 community-dwelling individuals from the Rush Memory and Aging Project.

Measurements and Results:

We obtained up to 11 days of actigraphic recordings in subjects' home environments and quantified the fragmentation of rest and activity using a recently developed state transition metric. We tested the associations between this metric and performance in 5 cognitive domains. Greater fragmentation of both rest and activity were associated with lower levels of cognitive performance, and this association was independent of total amounts of rest or activity. There was a characteristic pattern of cognitive deficits associated with rest and activity fragmentation, with preferential involvement of perceptual speed, semantic memory, working memory, and visuospatial abilities, and relative sparing of episodic memory.

Conclusions:

The fragmentation of periods of rest and activity is a clinically important characteristic of rest-activity patterns that correlates with cognitive performance in older individuals.

Citation:

Lim ASP; Yu L; Costa MD; Leurgans SE; Buchman AS; Bennett DA; Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. SLEEP 2012;35(5):633-640.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321422

DOI: 10.5665/sleep.1820
PubMed: 22547889
PubMed Central: 3321422

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals</title>
<author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff5">Wyss Institute for Biologically Inspired Engineering, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Wyss Institute for Biologically Inspired Engineering, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saper, Clifford B" sort="Saper, Clifford B" uniqKey="Saper C" first="Clifford B." last="Saper">Clifford B. Saper</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22547889</idno>
<idno type="pmc">3321422</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321422</idno>
<idno type="RBID">PMC:3321422</idno>
<idno type="doi">10.5665/sleep.1820</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000682</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000682</idno>
<idno type="wicri:Area/Pmc/Curation">000682</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000682</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000812</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000812</idno>
<idno type="wicri:Area/Ncbi/Merge">001136</idno>
<idno type="wicri:Area/Ncbi/Curation">001136</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001136</idno>
<idno type="wicri:doubleKey">0161-8105:2012:Lim A:increased:fragmentation:of</idno>
<idno type="wicri:Area/Main/Merge">001232</idno>
<idno type="wicri:Area/Main/Curation">001207</idno>
<idno type="wicri:Area/Main/Exploration">001207</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals</title>
<author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff5">Wyss Institute for Biologically Inspired Engineering, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Wyss Institute for Biologically Inspired Engineering, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saper, Clifford B" sort="Saper, Clifford B" uniqKey="Saper C" first="Clifford B." last="Saper">Clifford B. Saper</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Aging is accompanied by changes in cognitive function, and changes in rest-activity patterns. Previous work has demonstrated associations between global rest-activity measures and cognitive performance on a number of tasks. Recently, we demonstrated that aging is associated with changes in the minute-to-minute fragmentation of rest-activity patterns in addition to changes in amounts of rest and activity. Given the body of experimental evidence linking sleep fragmentation with decrements in cognitive function in animals and humans, we hypothesized that increased fragmentation of rest-activity patterns would be associated with decreased cognitive function in older individuals.</p>
</sec>
<sec><title>Design:</title>
<p>Cross-sectional.</p>
</sec>
<sec><title>Participants:</title>
<p>700 community-dwelling individuals from the Rush Memory and Aging Project.</p>
</sec>
<sec><title>Measurements and Results:</title>
<p>We obtained up to 11 days of actigraphic recordings in subjects' home environments and quantified the fragmentation of rest and activity using a recently developed state transition metric. We tested the associations between this metric and performance in 5 cognitive domains. Greater fragmentation of both rest and activity were associated with lower levels of cognitive performance, and this association was independent of total amounts of rest or activity. There was a characteristic pattern of cognitive deficits associated with rest and activity fragmentation, with preferential involvement of perceptual speed, semantic memory, working memory, and visuospatial abilities, and relative sparing of episodic memory.</p>
</sec>
<sec><title>Conclusions:</title>
<p>The fragmentation of periods of rest and activity is a clinically important characteristic of rest-activity patterns that correlates with cognitive performance in older individuals.</p>
</sec>
<sec><title>Citation:</title>
<p>Lim ASP; Yu L; Costa MD; Leurgans SE; Buchman AS; Bennett DA; Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. <italic>SLEEP</italic>
 2012;35(5):633-640.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Massachusetts</li>
<li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name>
</region>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name>
<name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name>
<name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name>
<name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name>
<name sortKey="Saper, Clifford B" sort="Saper, Clifford B" uniqKey="Saper C" first="Clifford B." last="Saper">Clifford B. Saper</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001207 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001207 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3321422
   |texte=   Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22547889" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals

Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.